Archive for the Uncategorized Category

The Electrical Sensing Zone technique aka….

coulter counter techniqueThe Electrical Sensing Zone technique (also known as the Coulter Counter) has been used as a method of particle size measurement since it’s development in the 1950’s. Originally developed for counting blood cells, it was quickly realised that the ‘Coulter Counter’ could be of great help in particle size analysis of almost any powder, suspension or emulsion, providing rapid, reliable and reproducible results.

Since the Coulter Counter measures the particle volume ( one of the few techniques to measure an actual particle parameter rather than an effect of the particle on light or settling rate) it produces a particle size distribution by volume(weight), but it also has the advantage that it measures the particles individually (particle counting) and provides a particle count or concentration measurement.

One of the highest resolution techniques available it can measure and show extremely small changes in particle size.  With a number of ISO and ASTM standards for different applications,  the Coulter Counter offers an established technique for particle characterisation.

A brief guide to particle counters

A particle counter is used to count and size particles directly, rather than other methods where numbers, volumes and sizes are estimated. Continue reading A brief guide to particle counters

But What Is a Coulter Counter?

What is a Coulter Counter

For the last couple of years I have been writing posts on Coulter Counter applications, developments and history, some of which have been quite detailed, but this month I thought I would pause and give a simple summary for those who are new to the subject. Continue reading But What Is a Coulter Counter?

Moving the Lab Forward

I’ve just been watching a short video on the Beckman Coulter website. Entitled ‘Lab Forward’, it’s one of several videos that really help to give a flavour of the company and its philosophy. Continue reading Moving the Lab Forward

Beckman Coulter’s Portfolio

Flow cytometry – Beckman Coulter

The story of the company founded by Dr Arnold O Beckman is one of non-stop innovation and expansion to ensure that scientists in the biomedical, life science and related fields have access to a full range of high-quality analytical instruments. As part of that growth, it has made a number of vital acquisitions – including that of the Coulter Corporation in 1997, which resulted in the new name Beckman Coulter. Continue reading Beckman Coulter’s Portfolio

Haematology

Haematology - glb_bci_153873Haematology – the branch of medicine concerned with study and treatment of the blood – was the very reason for the Coulter Counter’s invention and it continues to be at the heart (forgive the pun) of Beckman Coulter’s activities today. Continue reading Haematology

Beckman Coulter

Dr Arnold O Beckman

Dr Arnold O Beckman

If you’re a user of Coulter Counters and the Coulter Principle, you will undoubtedly know something of their inventor, Wallace H Coulter. His name lives on through his many achievements, and in the name of the company that continues to perfect and manufacture Coulter Counters today: Beckman Coulter. I would now like to tell you a little about that company and its founder, Dr Arnold O Beckman. Continue reading Beckman Coulter

Coincident Events

I’ve mentioned it before, but I think it’s well worth repeating, that Coulter Counter users can open up a mine of useful background information and application advice if they go to the Beckman Coulter website, www.beckmancoulter.com. Once you’re on the site, go to the relevant product section and then in the right-hand column click on ‘Literature’. In my latest search I came across some notes on ‘coincident events’ in relation to use of the Coulter Principle. Continue reading Coincident Events

Meritics – for Coulter Counters and More

Meritics logo

I hope the information on the Coulter Counter website is proving useful to you, but if you would like some further – and very authoritative – advice on the use of these instruments or any other particle and material characterisation technology you should speak to Meritics. Continue reading Meritics – for Coulter Counters and More

Rules and Regulations

Rules and regulations

I need hardly tell you that scientific instruments and their uses are governed by a lot of regulation. I for one find it very reassuring to know that the manufacturer of my analytical instruments is well aware of the relevant legislation and has taken the necessary steps to comply. In the following article I would like to mention two key regulatory areas in relation to Coulter Counters: use of electronic records and compliance with current Good Manufacturing Practices (cGMPs). Continue reading Rules and Regulations